TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS
نویسندگان
چکیده
Objective: The aim of the study was to investigate preventive effects Taurine against 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced organ damage in rats. environmental toxin TCDD has a high toxicity animal and human tissues. is an amino acid found cells that antioxidant properties anti-inflammatory. As result, potential effect taurine on oxidative stress caused by investigated rat liver kidney tissues measuring glutathione (GSH), superoxide dismutase (SOD) activity, thiobarbituric reactive substances (TBARS) levels.
 Material Method: Adult male Wistar rats (250-300 g, 12-13 weeks, n = 32) were randomly allocted into four groups (n 8/group): Control, TCDD, TAU, TCDD+TAU. and/or administered via gavage doses 2 μg/kg/week 200 mg/kg/day, respectively.
 Result Discussion: results showed decreasing levels GSH SOD activity increasing TBARS. treatment significantly reduced TBARS (p
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ژورنال
عنوان ژورنال: Ankara Üniversitesi Eczac?l?k Fakültesi dergisi
سال: 2023
ISSN: ['1015-3918', '2564-6524']
DOI: https://doi.org/10.33483/jfpau.1085253